Adiponectin : Implications in Health and Diseases: Adiponectin
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Adiponectin is the name originated from its distinctive molecular characteristics ("adipo" ] "nectin" = "adiponectin") as it is a product of novel gene apM1 which is specific to adipocytes and uniquely possess a collagen-like domain with a nectin-like adherent property. Adiponectin is the most abundant peptide secreted by adipocytes, whose altered levels play a central role in obesity-related diseases, including insulin resistance/type 2 diabetes and cardiovascular disease. It is known to exert anti-diabetic and anti-atherosclerotic effects via adiponectin receptors (Adipors); AdipoR1 and AdipoR2. Adiponectin has direct actions in liver, skeletal muscle and the vasculature. Adiponectin administration in humans and rodents has insulin-sensitizing, anti-atherogenic, and anti-inflammatory effects and in certain settings, also decreases body weight. Therefore, adiponectin replacement therapy in humans may suggest potential versatile therapeutic targets in the treatment of obesity, insulin resistance/type 2 diabetes, cardiovascular disease and atherosclerosis.
Format:Paperback
Language:English
ISBN:6138920910
ISBN13:9786138920915
Release Date:January 2020
Publisher:Scholars' Press
Length:68 Pages
Weight:0.25 lbs.
Dimensions:0.2" x 6.0" x 9.0"
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