Calcium concentrations are tightly regulated in various neuronal and cellular compartments. The recognition that even very slight imbalances of calcium, when sustained over a long period of time, could lead by intraneuronal processes to cellular deterioration and death has led to the formulation of the calcium hypothesis of aging. Many of the leading scientists in this multidisciplinary field present their latest work in this volume, work that advances an understanding of the role of calcium in reviews range broadly from considerations of calcium channel functions at the molecular level to the role of altered calcium levels in behaviour.
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