Genetic Toxicology: Principles and Methods

1. The Application of Structure Activity Relationships to the Prediction of the Mutagenic Activity of Chemicals

Philip Judson

2. Bacterial Mutagenicity Assays: Test Methods

David Gatehouse

3. The Mouse Lymphoma Assay

Melvyn Lloyd and Darren Kidd

4. Mammalian Cell HPRT Gene Mutation Assay: Test Methods

George E. Johnson

5. The In Vitro Mammalian Chromosome Aberration Test

Gill Clare

6. The Interpretation and Analysis of Cytogenetic Data

Natalie Danford

7. The In Vitro Micronucleus Assay

Ann T. Doherty

8. The In Vitro and In Vivo Comet Assays

Brian Burlinson

9. Assessment of DNA Interstrand Crosslinks (ICLs) Using the Modified Alkaline Comet Assay

Jian Hong Wu and Nigel J. Jones

10. 32P-Postlabelling for the Sensitive Detection of DNA Adducts

Nigel J. Jones

11. Methods for the Detection of DNA Adducts

Karen Brown

12. The GADD45a-GFP GreenScreen HC Assay

Richard M. Walmsley and Matthew Tate

13. Real Time Reverse-Transcription Polymerase Chain Reaction (RT-PCR): Technical Considerations for Gene Expression Analysis

Shareen H. Doak and Zoulikha M. Za?r

14. Cytogenetic In Vivo Assays in Somatic Cells

Ann T. Doherty, Adolph Baumgartner, and Diana Anderson

15. Cytogenetic Methods in Human Biomonitoring: Principles and Uses

Raluca A. Mateuca, Ilsa Decordier, and Micheline Kirsch-Volders

16. The Measurement of Induced Genetic Change in Mammalian Germ Cells

Ilse-Dore Adler, Francesca Pacchierotti, and Antonella Russo

17. Transgenic Animal Mutation Models: A Review of the Models and How They Function

Steve Dean

18. Analysis of Genotoxicity Data in a Regulatory Context

Ian de G. Mitchell and David O.F. Skibinski