Journeys in Pediatric Neuroblastoma Treatments: Insights and Advances

Journeys in Pediatric Neuroblastoma Treatments: Insights and Advances is a comprehensive collection of scientific journal articles that navigate the intricate landscape of neuroblastoma treatment. The foremost extracranial solid tumor in pediatric patients, neuroblastoma, presents diverse clinical challenges-from spontaneous regression to aggressive metastasis. This collection provides an in-depth exploration of the multifaceted approaches required for effective treatment. Readers will gain insights into the tri-phased treatment schema for high-risk neuroblastoma, including induction, consolidation, and maintenance phases. Cutting-edge immunotherapy strategies, such as CAR T cell therapy and novel monoclonal antibodies, are extensively reviewed. Articles delve into molecular underpinnings, highlighting miRNA-targeted therapies and the potential of mesenchymal stromal cells in targeted treatment delivery and hematopoietic recovery. Groundbreaking approaches like targeted radiotherapy with 131I-metaiodobenzylguanidine (MIBG) and oncolytic virotherapy using the Zika virus are also discussed. With contributions that span genetic, molecular, and alternative treatment avenues, this compendium is an essential resource for researchers, clinicians, and students dedicated to advancing neuroblastoma treatment. Dive into the dynamic and hopeful trajectory of neuroblastoma research and discover the potential for improved outcomes and survival rates in pediatric oncology.

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