Systems Biology in Drug Discovery and Development: Methods and Protocols

Part I: Methodologies of Systems Biology in Drug Discovery and Development 1. Proteomics and Systems Biology: Application in Drug Discovery and Development Bulbul Chakravarti, Buddhadeb Mallik, and Deb N. Chakravarti 2. Systems Biology Approaches and Tools for Analysis of Interactomes and Multi-Target Drugs Andr? Schrattenholz, Karlfried Groebe, and Vukic Soskic 3. Systems Biology "On-the-Fly" SILAC-Based Quantitative Proteomics and RNAi Approach in D. Melanogaster Alessandro Cuomo and Tiziana Bonaldi 4. Systems Biology of Cell Behaviour Najl V. Valeyev, Declan G. Bates, Yoshinori Umezawa, Antonina N. Gizatullina, and Nikolay V. Kotov 5. Computational Modeling in Systems Biology Ravishankar R. Vallabhajosyula and Alpan Raval 6. An Introduction to Gaussian Bayesian Networks Marco Grzegorczyk 7. Derivation of Large-Scale Cellular Regulatory Networks from Biological Time Series Data Benjamin L. de Bivort 8. Translational Bioinformatics and Systems Biology Approaches for Personalized Medicine Qing Yan Part II: Systems Biology Methods for Disease Treatment and Translational Medicine 9. Systems Biology and Inflammation Yoram Vodovotz and Gary An 10. Immunoinformatics and Systems Biology Methods for Personalized Medicine Qing Yan 11. Systems Biology Approaches to the Study of Cardiovascular Drugs Yuri Nikolsky and Robert Kleemann 12. Cancer Systems Biology Dana Faratian, James L. Bown, V. Anne Smith, Simon P. Langdon, and David J. Harrison 13. Systemic Lupus Erythematosus: From Genes to Organ Damage Vasileios C. Kyttaris 14. Systems Biology of Influenza: Understanding Multi-Dimensional Interactions for Personalized Prevention and Treatment Qing Yan 15. Methods in Systems Biology of Experimental Methamphetamine Drug Abuse Firas H. Kobeissy, Shankar Sadasivan, Melinda Buchanan, Zhiqun Zhang, Mark S Gold, and Kevin K.W. Wang 16. Systems Biology and Theranostic Approach to Drug Discovery and Development to Treat Traumatic BrainInjury Zhiqun Zhang, Stephen F. Larner, Firas Kobeissy, Ronald L. Hayes, and Kevin K.W. Wang