Pre-Clinical Models: Techniques and Protocols

Part I: Reviews

1. A Guide to Mass Spectrometry-based Quantitative Proteomics

Bradley J. Smith, Daniel Martins-de-Souza, and Mariana Fioramonte

2. Mitochondrial Involvement in Mental Disorders; Energy Metabolism, Genetic and Environmental Factors

Keiko Iwata

3. Monosodium Glutamate (MSG)-induced Animal Model of Type 2 Diabetes

Zahra Bahadoran, Parvin Mirmiran, and Asghar Ghasemi

Part II: Protocols

4. The Elevated Plus Maze Test for Measuring Anxiety-like Behaviour in Rodents

Ann-Katrin Kraeuter, Paul C. Guest, and Zolt?n Sarnyai

5. The Forced Swim Test for Depression-like Behaviour in Rodents

Ann-Katrin Kraeuter, Paul C. Guest, and Zolt?n Sarnyai

6. Object Burying Test for Assessment of Obsessive Compulsive Behaviours in Mice

Ann-Katrin Kraeuter, Paul C. Guest, and Zolt?n Sarnyai

7. The Nest Building Test in Mice for Assessment of General Well-being

Ann-Katrin Kraeuter, Paul C. Guest, and Zolt?n Sarnyai

8. Mouse Free Dyadic Social Interaction Test

Ann-Katrin Kraeuter, Paul C. Guest, and Zolt?n Sarnyai

9. The Open Field Test for Measuring Locomotor Activity and Anxiety-Like Behaviour

Ann-Katrin Kraeuter, Paul C. Guest, and Zolt?n Sarnyai

10. The Y-maze for Assessment of Spatial Working and Reference Memory in Mice

Ann-Katrin Kraeuter, Paul C. Guest, and Zolt?n Sarnyai

11. Maturation of a Human Oligodendrocyte Cell Line

Gabriela Seabra, Val?ria de Almeida, and Daniel Martins-de-Souza

12. Monitoring Age-related Changes in the Lactate/pyruvate Ratio using a Colorimetric Assay in a C. elegans Model of Increased Lifespan

Sumino Yanase, Kayo Yasuda, and Naoki Ishii

13. Isolation and Characterisation of Different Mesenchymal Stem Cell Populations from Rat Femur

Frans Alexander Jacobs, Mari van de Vyver, and William Frank Ferris

14. Characterization of an Animal Model of Autism and Social Interaction

Keiko Iwata

15. Assaying Reproductive Capacity in Female Rodents

Catherine E. Aiken, Jane L. Tarry-Adkins, and Susan E. Ozanne

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