Annie Pinkerton Boone Newcastle's wedding night is, well, memorable. One minute she's arrived from Iowa to the practically barbarian Arizona Territory for a pre-arranged marriage, the next her newly acquired--and much older--husband expires just after the honeymoon has begun, leaving Annie without funds, and the sole support of his two elderly relatives. To make matters worse, the dead geezer has the unmitigated gall to take up residence inside Annie's body.
However, the ghost of Jonas Newcastle makes himself useful by channeling vital information from the great beyond through Annie. The somewhat bewildered widow quickly earns a reputation as a seer, and soon she's sharing Jona's psychic "hints" with the public. The once impoverished widown becomes a celebrated figure, but even "Prophet Annie" cannot foresee all the raucous adventures and passionate fulfillment the future holds for her.