Protein Crosslinking: Nutritional and Medical Consequences

The word crosslinking implies durable combination of usually large, distinct elements at specific places to create a new entity that has different properties as a result of the union. In the case of proteins, such crosslinking often results in important changes in chemical, physical, functional, nutritional, and biome- dical properties, besides physical properties simply related to molecular size and shape. (Nucleic acids, carbohydrates glyco- proteins, and other biopolymers are correspondingly affected.) Since proteins are ubiquitous, the consequences of their crosslin- king are widespread and often profound. Scientists from many dis- ciplines including organic chemistry, biochemistry, protein chemis- try, food science, nutrition, radiation biology, pharmacology, physiology, medicine, and dentistry are, therefore, very much inte- rested in protein crosslinking reactions and their implications. Because protein crosslinking encompasses so many disciplines, in organizing the Symposium on Nutritional and Biochemical Consequences of Protein Crosslinking sponsored by the Protein Subdivision of the Division of Agricultural and Food Chemistry of the American Chemical Society, I sought participants with the broadest possible range of interests, yet with a common concern for theoretical and practical aspects of protein crosslinking. An important function of a symposium is to catalyze progress by bringing together ideas and experiences needed for interaction among different, yet related disciplines. To my pleasant surprize, nearly everone invited came to San Francisco to participate.