Part 1. ASOCC Theory and Platform.- Chapter 1. Introduction.- Chapter 2. Foundations.- Chapter 3. From Theories to Implementation.- Chapter 4. Simulation Use.- Part II. Scenario's and Submodels.- Chapter 5. Closing of Schools.- Chapter 6. Testing & Smart Testing.- Chapter 7. Deployment and Effects of an App for Tracking and Tracing Contacts.- Chapter 8. How Culture Influences the Management of a Pandemic: Simulating the Effect of Culture on the Effective Management of the COVID-19 crisis, - Chapter 9. Economics.- Chapter 10. Exit Strategies.- Part III. Results and Lessons Learned.- Chapter 11. Extensible Model-Building in Crises.- Chapter 12. Comparative Validation of Simulation Models for the COVID-19 Pandemic.- Chapter 13. Supporting Policy Makers in a Crisis.- Chapter 14. From Crisis to Resilience Support.- Chapter 15. Challenges and Issues.- Chapter 16. Conclusions.