This is an integrated and cross-disciplinary presentation of cell death research. It emphasises the pervasiveness of the phenomena and its importance in development, homeostasis, aging and disease. Encompassing the phenomena from genetics to signal transduction and observed manifestation, and presenting the work through model systems of life-forms ranging from nematodes to humans, the authors discuss the similarity and means of observing and studying the apoptotic and other forms of cell death. Emphasis is placed on the evaluation of the many indicators of cell death and on connecting the growing stories of cell death into a coherent framework.
This is the best available review of the subject of cell death. It is both comprehensive and thorough including both vertebrate and invertebrate animals as well as plants It covers cell death as part of development, the cell cycle, the immune system and many diseases including cancer, CNS and myocardial ischemia and Alzheimer's disease. It also includes thoughtful analyses of evolution and death in single-celled organisms. The authors of individual chapters are experts in their fields and the editors have done a noteworthy task in organizing the book into a coherent whole. It is indispensable for students, fellows and senior investigators interested in the subject.
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